Fig. 2: PubMed database was used to search literature related to OS and TKIs from 2000 to now, and the visual image of keyword distribution frequency was drawn, which showed that studies on TKIs in OS mostly focused on signal transduction, which was consistent with the action mechanism of TKIs. | Cell Death Discovery

Fig. 2: PubMed database was used to search literature related to OS and TKIs from 2000 to now, and the visual image of keyword distribution frequency was drawn, which showed that studies on TKIs in OS mostly focused on signal transduction, which was consistent with the action mechanism of TKIs.

From: Current progress and open challenges for applying tyrosine kinase inhibitors in osteosarcoma

Fig. 2

Keywords with the highest correlation included imatinib, IGF-1R, platelet-derived growth factor (PDGF), PI3K inhibitors, MAPK signaling pathway, etc.

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