Fig. 4: The research hotspot of TKIs resistance in OS.
From: Current progress and open challenges for applying tyrosine kinase inhibitors in osteosarcoma
According to the results of visual analysis, the distribution frequency of keywords of drug resistance-related studies of all TKIs in OS was shown in the figure, indicating that the research focuses on IGF-1R, ErbB receptor, AKT, and PI3K pathway.
