Fig. 8: Schematic diagram of the role of FHL1-mediated HOXA10 deacetylation in the regulation of blastocyst epithelial adhesion in RIF patients and fertile controls. | Cell Death Discovery

Fig. 8: Schematic diagram of the role of FHL1-mediated HOXA10 deacetylation in the regulation of blastocyst epithelial adhesion in RIF patients and fertile controls.

From: FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion

Fig. 8: Schematic diagram of the role of FHL1-mediated HOXA10 deacetylation in the regulation of blastocyst epithelial adhesion in RIF patients and fertile controls.

In endometrial epithelial cells, FHL1 increases HOXA10 deacetylation by promoting the interaction of SIRT2 and HOXA10, thereby enhancing HOXA10 target gene transcription and downstream pathway activation. This role of FHL1 in the endometrium involves the establishment of endometrial receptivity and the failure of blastocyst epithelial adhesion in RIF patients.

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