Fig. 3: MiR-6750-SEVs can be shuttled to Macrophage in TME to regulate macrophage phenotype. | Cell Death Discovery

Fig. 3: MiR-6750-SEVs can be shuttled to Macrophage in TME to regulate macrophage phenotype.

From: SEVs-mediated miR-6750 transfer inhibits pre-metastatic niche formation in nasopharyngeal carcinoma by targeting M6PR

Fig. 3: MiR-6750-SEVs can be shuttled to Macrophage in TME to regulate macrophage phenotype.The alternative text for this image may have been generated using AI.

A Representative images of CD163/CD68 in tissues collected from graph-depicted groups. B Student’s t-test between CD163 expression and NPC metastasis. C Statistical analyses of the association of CD163 level with survival time of the patients. Log-rank test. Staining score of CD163 in NPC tissue was defined as low expression (scores of 0–8) or high expression (scores of 9–16) by the X-tile Software. D Representative image of macrophages was shown (THP-1 cells were treated with or without PMA). E NPC cell dissemination and metastasis was analyzed by a zebrafish model. Arrowheads indicate disseminated tumor foci. F, G Transwell migration assays were performed to measure cell migration. Student’s t-test. H miR-6750 levels in Macrophage were measured by qRT-PCR. Student’s t-test. I M0 Macrophages treated with various SEVS was used to measure Macrophage phenotype by qRT-PCR assay. Student’s t-test.

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