Fig. 8: Schematic summary for the present study. | Cell Death Discovery

Fig. 8: Schematic summary for the present study.

From: UVA induces retinal photoreceptor cell death via receptor interacting protein 3 kinase mediated necroptosis

Fig. 8

UVA induced ROS production, DNA damage, along with RIPK3 activation and up regulation. RIPK3 but not RIPK1 in turn induces necroptosis by upregulation of MLKL expression and suppresses apoptosis by downregulation of Cleaved Caspase-8 and Cleaved Caspase-3. GSK 872 (RIPK3 inhibitor) can significantly attenuate UVA-induced cell death via RIPK3-mediated pathway.

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