Fig. 1: Gene amplification-driven SNHG6 was significantly upregulated in NSCLC and predicated a poor prognosis. | Cell Death Discovery

Fig. 1: Gene amplification-driven SNHG6 was significantly upregulated in NSCLC and predicated a poor prognosis.

From: Gene amplification-driven lncRNA SNHG6 promotes tumorigenesis via epigenetically suppressing p27 expression and regulating cell cycle in non–small cell lung cancer

Fig. 1

a 35 lncRNAs were found upregulated in NSCLC tumor tissues from GSE33532 (20 normals vs 80 tumors) and 16 lncRNAs were found upregulated in NSCLC tumor tissues from GSE29249 (6 normals vs 6 tumors); b UCA1 and SNHG6 were identified in both datasets; c SNHG6 was upregulated in numerous malignant tumors in the TCGA database; d SNHG6 was upregulated in NSCLC tumor tissues compared with normal tissues in unpaired samples (Normal = 108, Tumor = 1037); e The differential expression level of SNHG6 in 106 paired samples (paired student’s t-test); f SNHG6 was upregulated in NSCLC cell lines (A549, SPCA1, and H1299) compared with 16HBE (unpaired student’s t-test); g High expression of SNHG6 was associated with a poor prognosis (OS, overall survival, log-rank test); h SNHG6 expression was positively related to the copy number of SNHG6 in NSCLC (P < 0.001, r = 0.52, n = 989); i SNHG6 expression in different copy number alteration group. Variables were presented as the mean ± SD (Standard deviation). ***P < 0.001, **P < 0.01.

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