Fig. 2: Mechanisms of other pyroptosis pathways. | Cell Death Discovery

Fig. 2: Mechanisms of other pyroptosis pathways.

From: The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases

Fig. 2

In other pathways, GSDMs are processed by apoptotic caspases, granzymes, and other proteinases. Caspase-3 is activated by certain chemotherapeutic drugs, TNF-α, and caspase-8, then cleaves GADME and forms membrane pores. GSDMD and GSDMC are cleaved by caspase-8 directly. Granzyme B released by CAR-T cells promotes the activation of caspase-3 and cleaves GSDME directly. Granzyme A is released by NK cells and CD8+T cells to cleave GSDMB. GSDMA is cleaved by SpeB in keratinocytes to induce pyroptosis.

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