Table 1 Difference between regulated cell death pathways.
From: The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases
Cell death types | DNA | Nuclear | Cell plasma | Cell membrane | Inflammation | Remark |
|---|---|---|---|---|---|---|
Apoptosis | Ordered fragmentation | Condensation | Shrink, vesicle wrapped | Intact | × | Apoptosis body generates |
Necroptosis | Random fragmentation | Condensation | Swell, release | Rupture | √ | – |
Pyroptosis | Random fragmentation | Condensation | Swell, release | Rupture | √ | Inflammasome activation |
Autophagy | Random fragmentation | Condensation | Amorphous, vacuolization | Intact | × | Autophagic vacuoles generates |
Ferroptosis | Random fragmentation | Normal | Swell, release | Rupture | √ | Shrunken mitochondria, ruptured mitochondrial membrane |
