Fig. 3: Ectopic expression of human NSUN2 in vivo alleviated DOX-induced myocardial injury.
From: NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress
A Western blot detected the expression of NSUN2 protein in heart tissue after 4 weeks of NSUN2 or control AAV9 treatment (n = 4). B TUNEL detected the myocardial cell apoptosis in four groups of mice (n = 3, Bar = 50 µm). C M-mode ultrasonic representation of short-axis section. D Statistical chart of LVEF% and LVFS% of four groups of mice detected by small-animal ultrasound (n = 4). E Two-dimensional speckle tracking technology displays the diastolic phase (red) and systolic phase (blue) of the wall motion monitored by each tracer point in the order shown in the figure. The measurement data were shown as mean ± standard deviation and compared by Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001.
