Fig. 5: CircTRPS1-2 inhibits the tumorigenesis and metastasis of ESCC in vivo. | Cell Death Discovery

Fig. 5: CircTRPS1-2 inhibits the tumorigenesis and metastasis of ESCC in vivo.

From: Circular RNA circTRPS1-2 inhibits the proliferation and migration of esophageal squamous cell carcinoma by reducing the production of ribosomes

Fig. 5: CircTRPS1-2 inhibits the tumorigenesis and metastasis of ESCC in vivo.The alternative text for this image may have been generated using AI.

a Representative images of subcutaneous tumors from each group. b Growth curves based on weekly measurements of tumor volumes. c Tumor weights. d Numbers of superficial metastatic nodules in circTRPS1-2 knockdown group, based on IVIS 200 Spectrum analysis. e Representative lung metastases in circTRPS1-2 knockdown group, based on IVIS 200 Spectrum analysis. f Hematoxylin-eosin staining of lung metastatic nodules. Black arrows indicate metastatic nodule. Magnification, 200×. Scale bar, 50 µm. g Total number of metastatic nodules. Data are mean ± SD (n = 3 biologically independent samples). *P < 0.05, **P < 0.01. circTRPS1-2, circTRPS1-2 overexpression lentivirus; IVIS, in vivo imaging system; mock and sh-NC, negative control lentivirus; sh-circ, circTRPS1-2 shRNA interference lentivirus.

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