Fig. 3: Anti-VEGF-B and anti-IL-17A treatment simultaneously inhibited the renal fibrosis response in db/db mice of the DKD model. | Cell Death Discovery

Fig. 3: Anti-VEGF-B and anti-IL-17A treatment simultaneously inhibited the renal fibrosis response in db/db mice of the DKD model.

From: Simultaneous blockade of VEGF-B and IL-17A ameliorated diabetic kidney disease by reducing ectopic lipid deposition and alleviating inflammation response

Fig. 3: Anti-VEGF-B and anti-IL-17A treatment simultaneously inhibited the renal fibrosis response in db/db mice of the DKD model.The alternative text for this image may have been generated using AI.

A Deposition of collagen fiber was determined according to Masson staining of db/db mice kidney sections (scale bar: 10 μm). B and C Deposition of Collagen fiber deposition including α-SMA and fibronectin in kidney sections by immunohistochemistry analysis (scale bar: 10 μm). D Quantification of the collagen fiber deposition of Masson staining of db/db mice kidney sections. E and F Quantification of the expression of fibrosis markers of fibronectin and α-SMA in kidney sections in DKD mice after anti-VEGF-B or/and anti-IL-17A treatment. The data were presented as means ± SD, n = 4 mice in each group, per section/per mice, 5 glomerulus or tubulointerstitial/per section (D–F), ****P < 0.0001, **P < 0.01, *P < 0.05. The statistical significance was analyzed by one-way ANOVA with Tukey’s multiple-comparisons test.

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