Fig. 7: CFI-400945 causes dysregulation of centrosome duplication. | Cell Death Discovery

Fig. 7: CFI-400945 causes dysregulation of centrosome duplication.

From: Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis

Fig. 7

SMCs were treated with DMSO or different concentrations of CFI-400945 for 24 h, followed by overnight fixation with 100% methanol. Cells were stained for α-tubulin and γ-tubulin and the nuclei counterstained with DAPI. A Representative micrographs acquired with confocal microscopy showing the mitotic spindle (α-tubulin, green), centrosomes (γ-tubulin, red), and chromosomes (DNA, blue) of mitotic cells. B Percentages of cell populations are displayed according to centrosome number before or after CFI-400945 treatment.

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