Table 1 Serum biochemistry in WT and Tnfrsf12a KO mice with BDL for 7 days.

From: Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis

 

Sham operation, 7 days

BDL operation, 7 days

Liver function tests

WT (n = 8)

Tnfrsf12a KO (n = 8)

WT (n = 8)

Tnfrsf12a KO (n = 6)

Serum ALT (IU/L)

30.85 ± 10.23

25.10 ± 9.54

270.15 ± 127.46*¶

120.07 ± 58.72*¶§

Serum AST (IU/L)

88.50 ± 38.72

91.00 ± 33.78

596.95 ± 368.34*¶

221.13 ± 69.60*¶§

Serum ALP (IU/L)

129.50 ± 62.25

148.00 ± 75.50

540.50 ± 173.82*¶

351.67 ± 87.60*¶§

Serum TBA (μmol/L)

33.30 ± 47.33

9.90 ± 12.86

226.23 ± 117.47*¶

174.79 ± 203.35

Serum TBIL (μmol/L)

3.30 ± 2.29

3.78 ± 3.54

125.65 ± 79.23*¶

62.20 ± 55.46*¶

Serum DBIL (μmol/L)

1.34 ± 2.72

1.87 ± 3.46

88.83 ± 58.52*¶

30.49 ± 30.24*¶§

  1. BDL bile duct ligation, KO Knock out, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, TBA total bile salts, TBIL total bilirubin, DBIL Direct bilirubin.
  2. Values are means ± SD. *P < 0.05 VS Sham-WT mice; P < 0.05 VS Sham-Tnfrsf12a KO mice; §P < 0.05 VS BDL-WT mice.
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