Fig. 3: IGFBP7 expression was positively regulated by EMT signaling in GC. | Cell Death Discovery

Fig. 3: IGFBP7 expression was positively regulated by EMT signaling in GC.

From: Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis

Fig. 3

A Gene expression correlation analysis confirmed that IGFBP7 was related to EMT signaling in GC. B, C Expression level of IGFBP7 in the different subtypes of GC in GSE35809 and GSE62254 cohorts. D The expression of IGFBP7 was determined by qRT-PCR after TGF-beta treatment. E, F The expression correlation between IGFBP7 and OVOL2 in GC tissues and normal stomach tissues. G RNA-seq analysis was conducted in GC cells overexpressing OVOL2. IGFBP7 expression was decreased in GC cells overexpression OVOL2. H Quantitative RT-PCR assay showed that the expression of IGFBP7 was significantly reduced by OVOL2 in GC. ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05.

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