Fig. 5: IGFBP7 depletion suppressed FGF2 expression and secretion in GC. | Cell Death Discovery

Fig. 5: IGFBP7 depletion suppressed FGF2 expression and secretion in GC.

From: Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis

Fig. 5

A The differentially expressed genes after IGFBP7 depletion were shown in the heatmap. Among them, FGF2 was downregulated by knockdown of IGFBP7 in GC. B The expression correlation analysis between protein-coding genes and IGFBP7 was conducted in GC. C A total of 17 genes that co-expressed with IGFBP7 were greatly downregulated by IGFBP7 depletion in GC cell lines. D, E IGFBP7 was highly co-expressed with FGF2 in both GC tissues and normal stomach tissues. F, G RNA-seq and qRT-PCR analysis showed that IGFBP7 depletion decreased the expression of FGF2. H, I ELISA assay verified that IGFBP7 knockdown decreased secreted level of IGFBP7 and FGF2. **P < 0.01.

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