Fig. 6: IGFBP7 promotes TAM infiltration and FGF2 expression in GC. | Cell Death Discovery

Fig. 6: IGFBP7 promotes TAM infiltration and FGF2 expression in GC.

From: Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis

Fig. 6

A Single-cell analysis confirmed that IGFBP7 and FGF2 was specifically expressed in fibroblasts. B Immune estimation using EPIC method showed that IGFBP7 was highly expressed in CAFs of GC. C, D Immune infiltration analysis using TIMER or CIBERSOTR showed that IGFBP7 expression was highly associated with macrophage infiltration in GC. E, F Exogenous IGFBP7 treatment in macrophages downregulated the expression of M1 macrophage biomarkers, but upregulated expression of M2/TAM macrophage biomarkers. G, H Exogenous IGFBP7 treatment in GC cells upregulated FGF2 expression and secretion. **p < 0.01.

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