Fig. 1: Enrichment of epithelial-mesenchymal transformation-related genes from 33 cancer types.
From: Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling
A Gene expression data of 33 types of cancer were extracted from the TCGA dataset. The GO-bioprocess plot was generated by three major bio-functions: EMT, cell cycle, EMT and cell cycle process. As a result, 2930 genes significantly enriched in the intersection, with 69 receptor genes participating in the above three processes. The most significant positive and negative receptor genes were shown in the right table, and NEO1 was among them. B Overall Survival information and gene expression data of eight types of cancer patients were extracted from the TCGA dataset. The eight types of tumors involved are as follows: Tumor colon, glioma, tumor lung, kidney renal clear cell carcinoma, neuroblastoma, liver hepatocellular carcinoma, tumor breast, and melanoma. To describe the contribution of NEO1 to patient survival time, we used Kaplan–Meier analysis. 95% CI and p value were calculated via log-rank test and shown at the bottom of each plot.
