Fig. 7: A small regulatory network of functional genes for GC apoptosis and follicular atresia. | Cell Death Discovery

Fig. 7: A small regulatory network of functional genes for GC apoptosis and follicular atresia.

From: A regulatory network controlling ovarian granulosa cell death

Fig. 7

A NORFA levels were measured using qPCR in NORHA-overexpressing GCs. B NORHA levels were measured using qPCR in NORFA-overexpressing GCs. C This network comprises three ncRNAs (miR-187, NORHA, and NORFA), two feedback loops (NORFA-NFIX and NORHA-NORFA), and one signaling pathway (TGF-β). Four hub genes (NORHA, NORFA, miR-187, and TGFBR2) in this network are strongly associated with follicular atresia by influencing GC apoptosis. Red dotted arrows have been demonstrated by our previous studies [22, 24]. Data represent means ± SEM for three independent experiments. *p < 0.05.

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