Fig. 3: DHA increases intracellular iron and synergizes with low dose FAC treatment. | Cell Death Discovery

Fig. 3: DHA increases intracellular iron and synergizes with low dose FAC treatment.

From: Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein

Fig. 3: DHA increases intracellular iron and synergizes with low dose FAC treatment.The alternative text for this image may have been generated using AI.

a Fe2+ level assessed by Sirhonox straining after DH A or DHA + DFX treatment for 3 h in MOLM-14 or OCI-AML2. Data are expressed in in MFI (fold/DMSO-treated cells) (n = 3). b Immunoblotting analysis of CD71 and FTH1 in MOLM-14 and OCI-AML2 cells treated at increasing doses of DHA (1, 5 and 10 µM) for 24 h. c Immunoblotting analysis of IRP2, CD71 and FTH1 in MOLM-14 cells treated with FAC 10 µM, DHA 5 µM or both for 24 h. d Fe2+ level assessed by Sirhonox staining after DHA, FAC treatment or combination of both for 3 h. Data are expressed in mean fluorescence intensity (MFI) (fold/ DMSO treated cells) (n = 3).

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