Fig. 7: MT2A and MT1M genetic invalidation sensitizes cells to ferroptosis inducers. | Cell Death Discovery

Fig. 7: MT2A and MT1M genetic invalidation sensitizes cells to ferroptosis inducers.

From: Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein

Fig. 7

a Viability curves for the indicated cells at 24 h post treatment. Error bars ± standard deviation are shown (n = 6). b Heat maps showing IC50% of the indicated compounds after 24 h of exposure in MOLM-14 and OCI-AML2 cells transduced with shSCR, shMT2A or shMT2A and siMT1M for 48 h (n = 6). c C11-BODIPY staining of MOLM-14 and OCI-AML2 cells transduced with shSCR, shMT2A or shMT2A and siMT1M for 48 h and treated with DMSO, erastine (5 µM) or erastine + GSH (1 mM). Data are expressed in fold change compared to SCR non treated cells (n = 3). d Violin plots representing the viability in Uptiblue assay for three AML patients transduced with siSCR or siMT2A for 48 h and treated with DHA (50 µM) alone or DHA + PPG (2 mM) for 24 h.

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