Fig. 1: The mRNA expression of Sox8 was significantly downregulated in gouty arthritis rat models and MSU crystal-treated chondrocytes. | Cell Death Discovery

Fig. 1: The mRNA expression of Sox8 was significantly downregulated in gouty arthritis rat models and MSU crystal-treated chondrocytes.

From: Downregulation of Sox8 mediates monosodium urate crystal-induced autophagic impairment of cartilage in gout arthritis

Fig. 1

Volcano plot (A) and heatmap (B) of the mRNA sequencing result of cartilage from control group and gouty arthritis models. In the volcano plot, the green ones stand for downregulated genes and the red ones for upregulated genes; C and M in plots stands for control and model (gouty arthritis models) group respectively. In the heatmap, the blue ones represent downregulated genes and the red ones for upregulated genes. GSEA (C) illustrated the differentially identified genes. C28/I2 cells were incubated with MSU (200 μg/mL) for 24 h and Sox8 mRNA determined. The expression of Sox8 mRNA was significantly decreased both at mRNA level (D) and at protein level (E). The protein expression of Sox8 (F and G) in the cartilage of gouty arthritis rat models and the controls. Cartilage was stained with blue and Sox8 was stained yellow.

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