Fig. 6: The effect of Tp53+/− on genomic mutations in drug-resistant mice. | Cell Death Discovery

Fig. 6: The effect of Tp53+/− on genomic mutations in drug-resistant mice.

From: Tp53 haploinsufficiency is involved in hotspot mutations and cytoskeletal remodeling in gefitinib-induced drug-resistant EGFRL858R-lung cancer mice

Fig. 6: The effect of Tp53+/− on genomic mutations in drug-resistant mice.The alt text for this image may have been generated using AI.

Total genomic RNA was isolated from lung tissues of drug-resistant mice (EGFRL858R) with or without the Tp53+/− genotype, EGFRL858R*Tp53+/+ (n = 1) and EGFRL858R*Tp53+/− (n = 1), for whole-genome sequencing (WGS). The percentages of sequence mutations in the various regions of the whole-genome sequence (WGS) are shown here (A). The SNP and InDel profiles in drug-resistant mice with or without the TP53+/− mice were used to study the related pathways by Circus plot. The Chromosome 11 was highlighted (B). Genes with nonsynonymous mutations in the Chromosome 11 of drug-resistant mice with or without Tp53+/− were shown here in detail (C).

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