Fig. 6: MALAT1 promoted the osteogenic differentiation through inhibiting NEDD4 by targeted upregulating Runx1. | Cell Death Discovery

Fig. 6: MALAT1 promoted the osteogenic differentiation through inhibiting NEDD4 by targeted upregulating Runx1.

From: GATA4-activated lncRNA MALAT1 promotes osteogenic differentiation through inhibiting NEDD4-mediated RUNX1 degradation

Fig. 6

Cells were divided into four groups: Control, shNC, shMALAT1 and shMALAT1 + shNEDD4. A The mRNA expression of NEDD4 in different groups. B The expression of Runx1, ALP, OCN and OSX. C The analysis of ALP activity in different groups. D Representative images of ALP staining. E The analysis of osteogenic calcification. Mean ± SD, n = 3, *p < 0.05, **p < 0.01, ***p < 0.001. Statistical analysis was carried out by one-way ANOVA.

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