Fig. 7: GATA4 facilitated the bone formation in OVX mice by upregulating MALAT1. | Cell Death Discovery

Fig. 7: GATA4 facilitated the bone formation in OVX mice by upregulating MALAT1.

From: GATA4-activated lncRNA MALAT1 promotes osteogenic differentiation through inhibiting NEDD4-mediated RUNX1 degradation

Fig. 7

Mice were divided into five groups: Sham, OVX, OVX + oeNC+shNC, OVX + oeGATA4+shNC and OVX + oeGATA4 + shMALAT1 (n = 6). A, B Histological assessment of ectopic bone formation through HE and Masson staining. C Representative images of IHC staining to evaluate the expression of Runx1. D The expression of NEDD4, Runx1, ALP, OCN and OSX was measured by Western blotting. Mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001. Statistical analysis was carried out by one-way ANOVA.

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