Fig. 1: Senescence is linked to diabetic wounds.
From: Defective NCOA4-dependent ferroptosis in senescent fibroblasts retards diabetic wound healing
a A hypothesized model of the impact of NCOA4 deficiency in senescent fibroblasts within diabetic wounds. b Representative H & E staining and immunostaining of p16 photomicrographs illustrating the architecture of diabetes wounds (DW) and normal skin (NS). Scale bar = 200 μm. c Quantification of p16 immunostaining in b. d The mRNA level of p16 were detected by real-time PCR in normal glucose cultured fibroblasts (NG) and high glucose cultured fibroblasts (SF). e SA-β-GAL staining illustrates increased senescent fibroblasts after high glucose culture. Scale bar = 100 μm. Data represent the mean ± SEM of triplicates. *P < 0.05; ****P < 0.0001.
