Fig. 3: Structural basis for inhibition of ASC oligomerization by rB7. | Cell Death Discovery

Fig. 3: Structural basis for inhibition of ASC oligomerization by rB7.

From: Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space

Fig. 3

A One protomer structure of rB7 in complex with ASCPYD. rB7 and ASCPYD are shown in the cartoon model. Two interaction regions are presented in detail in (B) and (C). B Hydrogen bonds and salt bridges are shown in dashed lines in the stick model. C Hydrogen bonds are represented in light pink, and salt bridges are represented in pale cyan. D Superimpose of rB7 in complex with ASCPYD on Cryo-EM structure of ASCPYD filament (PDB ID: 3J63). rB7 and ASCPYD are presented in the cartoon model, and ASCPYD filaments are shown in the surface model. Seven molecules of ASCPYD are found nearby, and the steric clash with rB7 is highlighted in red.

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