Fig. 8: Model of functional interaction between IGF2BP3 and MMP3 in cardiac regeneration.

MI-induced signals activate IGF2BP3 expression in CMs. IGF2BP3 in turn stabilizes MMP3 mRNA by interacting with m6A methylation modification through the KH3 and KH4 domains. MMP3 may be implicated in remodeling the ECM to promote CM proliferation and regeneration.