Fig. 2: PLEKHG5 is upregulated in HCC and correlated with the prognosis of HCC patients. | Cell Death Discovery

Fig. 2: PLEKHG5 is upregulated in HCC and correlated with the prognosis of HCC patients.

From: PLEKHG5 is stabilized by HDAC2-related deacetylation and confers sorafenib resistance in hepatocellular carcinoma

Fig. 2

A, B Representative IHC images and H-score of PLEKHG5 protein expression in HCC tumor tissues and adjacent nontumor tissues from The Human Protein Atlas database. C, D Relative quantification of PLEKHG5 protein levels in HCC patients which were performed by western blot. Totally 32 pairs of HCC/ adjacent tissues were tested, and 29 pairs of PLEKHG5-detectable tissues were used for quantitative analysis. GAPDH served as the loading control. E, F IHC images and H-score of PLEKHG5 in HCC tissue of HCC patient cohort. G, H Kaplan-Meier estimation of PLEKHG5 OS and PFS based on the PLEKHG5 expression levels in the HCC patient cohort. I PLEKHG5 mRNA levels in HCC and paired non-tumor tissues from TCGA-LIHC dataset. J Overall survival curves of TCGA-LIHC analysis were performed by using ucscxenashiny tool in Hiplot (https://hiplot.com.cn), a comprehensive web platform for scientific data visualization. K, L Immunohistochemistry of PLEKHG5 in HCC tissue of patients from (C). The positive intensity was quantified by ImageJ Pro Plus. Error bars represent the mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, one-way ANOVA analysis.

Back to article page