Fig. 1: MPA treatment changed the genic signature of endometrial cancer and breast cancer cells. | Cell Death Discovery

Fig. 1: MPA treatment changed the genic signature of endometrial cancer and breast cancer cells.

From: TRPS1 regulates the opposite effect of progesterone via RANKL in endometrial carcinoma and breast carcinoma

Fig. 1

A Heatmap of differentially expressed genes in Ishikawa and T47D cells treated with MPA (20 μM for 48 h) versus DMSO. B Volcano plot showing the differentially expressed genes (DEGs) between the MPA-treated and DMSO groups. C Venn diagram to identify the common genes of significantly downregulated transcripts in Ishikawa and the significantly upregulated transcripts inT47D cells after treatment with 20 μM MPA for 48 h. D Venn diagram of the significantly upregulated transcripts in Ishikawa and the significantly downregulated transcripts in T47D cells after MPA treatment. E GO and pathway analyses of the 108 overlapping significantly altered common genes. F GSEA showing the enrichment of gene sets in DMSO- or MPA-treated Ishikawa and T47D cell lines. G The validation experiments by RT-PCR in Ishikawa and T47D cells. *p < 0.05. ns not significant.

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