Fig. 4: TRPS1 may be involved in forming a PR/TRPS1/HDAC2 complex to exert its effect on cancer cells. | Cell Death Discovery

Fig. 4: TRPS1 may be involved in forming a PR/TRPS1/HDAC2 complex to exert its effect on cancer cells.

From: TRPS1 regulates the opposite effect of progesterone via RANKL in endometrial carcinoma and breast carcinoma

Fig. 4

A The present of the enriched motif of PR by ChIP-seq assay. B The correlation between PR and TRPS1 was explored by GEPIA database in EC and BC, respectively. C Heatmap of GATA family members in EC based on GSE29436 and heatmap of GATA family members in BC according to GSE107209. D Exploration of the expression of TRPS1 in different kinds of tumors by GEPIA database. Each dots represented the expression of samples. E Promoter methylation level of TRPS1 in normal and tumor tissues of endometrium and mammary gland in TCGA dataset, respectively. F Immunohistochemical analysis of TRPS1 expression in normal and tumor samples of endometrium and mammary gland, respectively. G The mutual correlation between TRPS1 and HDAC2 was investigated by GEPIA website in EC and BC, respectively. H HEK-293T cells were co-transfected with HA-PGR and His-TRPS1, or His-TRPS1 and Flag-HDAC2 for 36 h and cell lysates were prepared for co-IP assays. *p < 0.05.

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