Table 2 The role of m6A regulators in gastric cancera,b.
From: Role of N6-methyladenosine RNA modification in gastric cancer
Regulator | Role in m6A modification | Function in gastric cancer | Abnormal change | Prognosis | Relevant mechanisms / targets | Reference |
|---|---|---|---|---|---|---|
METTL3 | Writer | Oncogene Promotes GC growth, proliferation, invasion, migration, chemoresistance, angiogenesis, metastasis, and EMT | Upregulated | Poor | METTL3/m6A/SOCS2 METTL3/m6A/YAP1 METTL3/m6A/PBX1/GCH1/BH4 LINC02253/METTL3/m6A/KRT18/MAPK/ERK miR-4429/METTL3-IGF2BP1/m6A/SEC62 SP1-METTL3-IGF2BP1/m6A/LncRNA THAP7-AS1/PI3K/AKT METTL3-YTHDF1/m6A/SPHK2/KLF2 ARHGAP5-AS1/METTL3/m6A/ARHGAP5 METTL3-YTHDF1/m6A/PARP1/BER METTL3-IGF2BP3/m6A/HDGF METTL3-YTHDF2/m6A/ADAMTS9 METTL3/m6A/HDGF/GLUT4/ENO2 METTL3/m6A/pri-miR17-92/PTEN/TMEM127/AKT/mTOR HBXIP/METTL3/m6A/MYC METTL3/m6A/ZMYM1-CtBP-LSD1-CoREST/E-cadherin/EMT HOXA10/METTL3/m6A/TGFβ/Smad/E-cadherin/EMT | [60] [61] [62] [65] [66] [67] [68] [69] [70] [71] [72] [71] [75] [76] [77] [78] |
METTL14 | Writer | Oncogene Promotes GC proliferation, invasion, and migration Suppressor Inhibits GC growth, proliferation, and invasion | unknown Downregulated | Poor Poor | METTL14/m6A/LINC01320/miR-495-5p/RAB19 METTL14/m6A/circORC5/miR-30c-2-3p/AKT1S1 | [79] [80] |
WTAP | Writer | Oncogene Promotes GC tumor growth, cell proliferation and Warburg effects | Upregulated | Poor | WTAP/m6A/HK2 | [82] |
KIAA1429 (VIRMA) | Writer | Oncogene Promotes GC cell aerobic glycolysis | Upregulated | Poor | KIAA1429/m6A/LINC00958/GLUT1 | [83] |
METTL16 | Writer | Oncogene Promotes GC cell proliferation and tumor growth | Upregulated | Poor | METTL16/m6A/cyclinD1 | [84] |
FTO | Eraser | Oncogene Promotes GC proliferation, invasion, migration, tumor growth and metastasis, mitochondrial metabolism, and cell apoptosis | Upregulated | Poor | HDAC3/FOXA2/FTO/m6A/MYC FTO/m6A/HOXB13/PI3K/AKT/mTOR PPI/FTO/m6A/mTORC1/DDIT3 FTO/m6A/caveolin-1 | [85] [86] [90] [87] |
ALKBH5 | Eraser | Oncogene Promotes GC proliferation, invasion, and metastasis | Upregulated | Poor | ALKBH5/m6A/lncRNA NEAT1/EZH2 ALKBH5-LncRNA NRON/m6A/NANOG | [91] [92] |
Suppressor Inhibits GC invasion and migration | Downregulated | Improved | ALKBH5/m6A/PKMYT1 | [93] | ||
YTHDC2 | Reader | Oncogene Promotes GC progression | Upregulated | Poor | YTHDC2/m6A/YAP/YTHDC2 Positive feedback loop | [94] |
YTHDF1 | Reader | Oncogene Promote GC proliferation, invasion, tumorigenesis, and lung metastasis | Upregulated | Poor | YTHDF1/m6A/USP14 YTHDF1/m6A/FZD7/Wnt/β-catenin | [95] [46] |
YTHDF2 | Reader | Suppressor Inhibits GC proliferation, invasion, and migration | Downregulated | Improved | YTHDF2/m6A/FOXC2 | [96] |
IGF2BP1 | Reader | Oncogene Promotes GC proliferation, migration, and aerobic glycolysis | Upregulated | Poor | IGF2BP1-METTL3/m6A/SEC62 IGF2BP1/m6A/c-MYC | [66] [98] |
IGF2BP2 | Reader | Oncogene Promotes GC proliferation and migration | Upregulated | Poor | IGF2BP2/m6A/SIRT1 IGF2BP2/m6A/IGF1R/RhoA-ROCK | [99] [100] |
IGF2BP3 | Reader | Oncogene Promotes GC invasion and migration | Upregulated | Poor | IGF2BP3/m6A/PKMYT1 | [93] |
