Fig. 7: NRF2-mediated transcriptional activation of Caspase-11 and HMGB1 release from autophagy-deficient hepatocytes. | Cell Death Discovery

Fig. 7: NRF2-mediated transcriptional activation of Caspase-11 and HMGB1 release from autophagy-deficient hepatocytes.

From: NRF2 transcriptionally regulates Caspase-11 expression to activate HMGB1 release by Autophagy-deficient hepatocytes

Fig. 7

LPS stimulated macrophages cause HMGB1 active release through activation of NLRP3, Capase-11 inflammasomes leading to activation of Caspase-1 and subsequent cleavage of Gasdermin D(GSDMD). Active release of HMGB1 by autophagy-deficient hepatocytes is mediated by transcriptional activation of Caspase-11 by NRF2, in which NLRP3 and GSDMD can be dispensed.

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