Fig. 1: Downregulation of miR-375 was associated with poor prognosis in LUSC. | Cell Death Discovery

Fig. 1: Downregulation of miR-375 was associated with poor prognosis in LUSC.

From: MicroRNA-375 restrains the progression of lung squamous cell carcinoma by modulating the ERK pathway via UBE3A-mediated DUSP1 degradation

Fig. 1

A Representative pictures of the RNAscope assay showing the expression of miR-375 in cancer and paracarcinoma tissues, magnification ×40 and ×200, respectively. B The scores of miR-375 expression in cancer and paracarcinoma tissues. C, D MiR-375 expression levels in unpaired (C) and paired (D) LUSC tissues (n = 502) and normal tissues (n = 49) from TCGA. E The ROC curve distinguished normal from LUSC tumor tissue, with an AUC of 0.801. F Relationship between miR-375 expression and OS was assessed by a Kaplan–Meier plot. The log-rank test was conducted to indicate statistically significant differences among the survival curves. G qRT-PCR of the expression of miR-375 in four LUSC cell lines compared to that in HBE cells. Amplification of U6 served as an internal control.

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