Fig. 4: NF-κB inhibitors attenuated kidney injury in Tim-3 knockout mice. | Cell Death Discovery

Fig. 4: NF-κB inhibitors attenuated kidney injury in Tim-3 knockout mice.

From: Tim-3 protects against cisplatin nephrotoxicity by inhibiting NF-κB-mediated inflammation

Fig. 4: NF-κB inhibitors attenuated kidney injury in Tim-3 knockout mice.The alt text for this image may have been generated using AI.

C57/BL6 wild-type and Tim-3 knockout mice were stimulated by cisplatin (30 mg/kg) with and without PDTC or TPCA1. A, B Serum creatinine and BUN values were determined. C Immunohistochemistry staining for phosphor-p65 and cleaved caspase 3 in the kidneys of different groups; Representative HE staining of kidney cortex tissues. Bar = 100 μm. D Quantitative IOD analysis of the level of phosphor-p65 by immunohistochemical staining. E Tubular damage score was semi-quantified according to HE staining results. F Quantitative IOD analysis of the level of cleaved caspase 3 by immunohistochemical staining. Data represent mean ± SD (n = 4–5 per group). Statistical significance was determined using two-way ANOVA followed by Tukey’s post hoc test. The experiments were repeated at least three times.

Back to article page