Fig. 7: TIAM2 mediates NSUN2-induced cell proliferation, migration and invasion of PC cells. | Cell Death Discovery

Fig. 7: TIAM2 mediates NSUN2-induced cell proliferation, migration and invasion of PC cells.

From: NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer

Fig. 7

A Western blot was conducted to examine TIAM2 expression in the Vector+siCtrl, NSUN2+siCtrl, Vector+siTIAM2, NSUN2+siTIAM2 cells. B Cell viability of indicated cells was determined by CCK-8 assays. C–E EdU staining assays for indicated cells. F, G The ability of colonies formation for indicated cells. H-I The migration ability and J, K invasion ability of indicated cells was evaluated by Transwell assays. L GSEA indicated that EMT pathway was enriched in the patients with high TIAM2 expression. M TIAM2 silence could suppress EMT-related genes expression and rescue these genes expression upregulated by NSUN2. Scale bar = 100 μm. Data are shown as the mean ± SD of 3 independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page