Fig. 3: The immortalized MEFs are widely divergent from wildtype MEFs.
a Chart showing the number of significantly differentially regulated genes up (+) or down (−) regulated (Bonferroni-Hochberg corrected p-value of <0.01 and a minimum fold-change of 2). b Correlation (R2) of the immortalized MEF lines compared to the wildtype MEFs. c Selected GO terms from the significantly up or downregulated genes from the transformed MEF lines. A term was considered significant if it had a Bonferroni-Hochberg corrected p-value of <0.01). See also Fig. S4b for the full table. d Boxplots for the genes defined as the MEF-senescent signature or the reprogramming-capable signature from Fig. S1c. Significance is from a two-sided Welch’s t-test for pair-wise comparisons versus MEFICR wildtype Passage 2 as the reference. A change was considered significant if the p-value was <0.01. Significant changes are colored red or blue.
