Fig. 4: FOXM1-mediated FA metabolism inhibits ferroptosis in GBM cells.
From: FOXM1 maintains fatty acid homoeostasis through the SET7-H3K4me1-FASN axis
A Cells were treated with the ferroptosis inducer (1 S,3 R)-RSL3, and the relative cell viability was evaluated. Error bar represent three independent experiments, ***p < 0.001. B Viability of each cell line with the indicated modifications. Error bar represent three independent experiments, ***p < 0.001. C, D The total ROS level was measured in each cell line with the indicated modifications. Error bar represent three independent experiments, ***p < 0.001. E, F The indicated cells were treated with a ferroptosis inducer and incubated with BODIPY C12 to detect the nonoxidized/oxidized lipids; scale bar, 20 μm. G, H Lipid ROS levels in cells with the indicated modifications. Error bar represent three independent experiments, ***p < 0.001.
