Fig. 8: Schematic representation for BEL-mediated BRD4/Nox4/ROS signalling inhibiting during ISO-induced cardiac hypertrophy. | Cell Death Discovery

Fig. 8: Schematic representation for BEL-mediated BRD4/Nox4/ROS signalling inhibiting during ISO-induced cardiac hypertrophy.

From: Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4

Fig. 8

BEL repressed BRD4 to reduce the ISO-induced acetylation of H3K122 and phosphorylation of RNA Pol II. Thus, the Nox4/ROS/ADAM17 signalling pathway was inhibited by BEL in a BRD4 dependent manner. Cardiac hypertrophy marker genes, including ANP, BNP, and β-MHC, were inhibited by BEL both in mice and in H9C2 cells. BEL alleviated cardiac hypertrophy and cardiac dysfunction via the BRD4/Nox4/ROS axes during ISO-induced cardiac hypertrophy.

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