Fig. 5: Delayed step-by-step rather than immediate decompression significantly reduces the severity of skeletal muscle in CI. | Cell Death Discovery

Fig. 5: Delayed step-by-step rather than immediate decompression significantly reduces the severity of skeletal muscle in CI.

From: Delayed step-by-step decompression with DSF alleviates skeletal muscle crush injury by inhibiting NLRP3/CASP-1/GSDMD pathway

Fig. 5: Delayed step-by-step rather than immediate decompression significantly reduces the severity of skeletal muscle in CI.

a Schematic drawing of the experimental design of delayed step-by-step decompression treatment for CI mice. CI represents that the mouse was crushed under 1.5 kg for 2 h or 12 h. CI/SR represents that the mouse was crushed under 1.5 kg for 2 h or 12 h, then maintained squeezed under 0.5 kg pressure for an additional 2 h. CI/R represents that the mouse was crushed under 1.5 kg for 2 h or 12 h, then directly decompression and reperfusion for 2 h. b–d CK, Mb, and LDH concentration in serum. e HE staining analyses skeletal muscle pathological changes under different crush conditions for 2 h and 12 h (NC, CI, CI/SR, CI/R) (original magnification: 400×; scale bar: 100 μm). Two-way ANOVA was used in (b–d) (n = 9).

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