Fig. 6: Knockdown of FOXD1 suppresses the growth of tumors in vivo. | Cell Death Discovery

Fig. 6: Knockdown of FOXD1 suppresses the growth of tumors in vivo.

From: miR-30e-5p-mediated FOXD1 promotes cell proliferation by blocking cellular senescence and apoptosis through p21/CDK2/Rb signaling in head and neck carcinoma

Fig. 6: Knockdown of FOXD1 suppresses the growth of tumors in vivo.The alternative text for this image may have been generated using AI.

A Tumors in group sh-FOXD1#1 were notably smaller than those in group sh-FOXD1#NC. B Tumor volumes in the FOXD1 sh-NC and sh-FOXD1 groups. C Tumor weights in the FOXD1 sh-NC and sh-FOXD1 groups. D IHC was performed on the mouse tumor tissues to evaluate the expression of FOXD1, p21, p-CDK2, p-Rb, and Ki67 (a proliferation marker). Immunohistochemistry score (E) and proliferation index (F) of the expression levels of FOXD1, p21 p-CDK2, p-Rb, and Ki67. G TUNEL assay indicated that the sh-FOXD1 group had more apoptotic cells than the sh-NC group. *p < 0.05, **p < 0.01, and ***p < 0.001. FOXD1 forkhead box D1, p-CDK2 phosphorylated cyclin-dependent kinase 2, p-Rb phosphorylated retinoblastoma, TUNEL terminal deoxynucleotidyl transferase dUTP nick end labeling, SEM standard error of the mean.

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