Fig. 6: Model of the sensitizing effect of PME-1 to oxidative stress-induced cell death in GBM. | Cell Death Discovery

Fig. 6: Model of the sensitizing effect of PME-1 to oxidative stress-induced cell death in GBM.

From: PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling

Fig. 6

A Visual representation of oxidative stress-induced PP2A-B55α binding to PME-1 and subsequent PP2A-C demethylation and inactivation in the nucleus (created with BioRender.com). B Model of the PP2A-B55α-inactivating function of PME-1 that subsequently controls activation of the MAPKAPK2-RIPK1 pathway and induction of RIPK1-dependent cell death (necroptosis) (created with BioRender.com).

Back to article page