Fig. 6: SOCS3 inhibits neutrophil differentiation but promotes monocyte/macrophage differentiation.
From: Selective activation of STAT3 and STAT5 dictates the fate of myeloid progenitor cells
A, B The mEB8-ER cells were infected by retroviral particles containing socs3-shRNA (A) or socs3 over-expression sequence (B). Then, the β-estradiol was removed from the medium for mEB8-ER cells, and the cells were differentiated without (Control, CTL) or with the induction of 2 ng/mL G-CSF and GM-CSF for 5 days. The morphological changes were evaluated with Wright-Giemsa staining (left). The bar stands for 50 μm. The cell number of the indicated types was counted (right). The details of statistical analyses on cell numbers in indicated types were shown in Fig. S6.
