Fig. 8: ZHX2 promotes I-125-induced anticancer effect in HCC via regulating GADD34. | Cell Death Discovery

Fig. 8: ZHX2 promotes I-125-induced anticancer effect in HCC via regulating GADD34.

From: Characterization of circSEC11A as a novel regulator of Iodine-125 radioactive seed-induced anticancer effects in hepatocellular carcinoma via targeting ZHX2/GADD34 axis

Fig. 8

A The western blot was performed to detect the expression level of ZHX2, GADD34, eIF2α, ATF4, and CHOP in SMMC7721 cells transfected with NT-RNAi or ZHX2-RNAi and I-125. B, C The flow cytometry and wound healing to detect cell cycle and cell migration ability treated with I-125, ZHX2-RNAi, and GADD34-siRNA in SMMC7721 cells. D Schematic illustration of circSEC11A/miR-3529-3p/ZHX2/GADD34 axis in regulating I-125-induced anti-cancer effect in HCC. The data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page