Fig. 1: Schematic design of a macrophage-mediated drug delivery system.
From: Nanoparticles carrying paclitaxel and anti-miR-221 for breast cancer therapy triggered by ultrasound
Perfluoropentane (PFP), paclitaxel (PTX), and anti-miR-221 were loaded into shells to form the nanoparticles with full components (PANPs) and then incubated with macrophages at 37 °C in the cell culture medium to obtain RAW-PANP. After injection into mice through the tail vein, a small fraction of PFP produced small bubbles in response to low-intensity ultrasound, enabling real-time tracking in vivo. Macrophages carrying PANPs accumulated within the tumor tissues. Upon high-intensity ultrasound, the remaining PFP burst, releasing PTX and anti-miRNA.
