Fig. 7: RBM47 restrained RCC progression and activated p53 signaling through HOXB-AS1. | Cell Death Discovery

Fig. 7: RBM47 restrained RCC progression and activated p53 signaling through HOXB-AS1.

From: RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1

Fig. 7

A The mRNA expression of p21, GADD45A, and GADD45B in RCC cells upon RBM47 knockdown or overexpression. B The protein expression of p53, p21, GADD45A, and GADD45B in RCC cells upon RBM47 knockdown or overexpression. C CCK-8 assays showing the growth curve of RCC cells upon RBM47 overexpression with or without HOXB-AS1 overexpression. D Transwell migration assays showing the metastatic ability of RCC cells upon RBM47 overexpression with or without HOXB-AS1 overexpression. E The mRNA expression of p21, GADD45A, and GADD45B in RCC cells upon RBM47 overexpression with or without HOXB-AS1 overexpression. F The protein expression of p53, p21, GADD45A, and GADD45B in RCC cells upon RBM47 overexpression with or without HOXB-AS1 overexpression. Data are presented as mean ± SD in three independent experiments. **p < 0.01; ***p < 0.001.

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