Fig. 1: PD and LID model validation and NONRATT023402.2 and behavioral characteristics of long-term LID models. | Cell Death Discovery

Fig. 1: PD and LID model validation and NONRATT023402.2 and behavioral characteristics of long-term LID models.

From: The NONRATT023402.2/rno-miR-3065-5p/NGFR axis affects levodopa-induced dyskinesia in a rat model of Parkinson’s disease

Fig. 1: PD and LID model validation and NONRATT023402.2 and behavioral characteristics of long-term LID models.

A Typical AIM included axial, forelimb, orolingual, and locomotive dyskinesia. B The protein level of TH and c-Fos in the right striatum of the Sham group, PD group, and LID group rats (n = 3). C Representative photomicrographs of TH immunofluorescence in coronal brain sections of the striatum and substantia nigra of rats subjected to 6-OHDA injection into the right striatum with L-DOPA administration. D Performance in the cylinder test of the Sham group, PD group, and LID group rats during a 3 week course (n = 5–6). E Average AIM scores of LID rats treated with L-DOPA for 2, 4, 6, 8, and 10 weeks on the day before being sacrificed (n = 4–5). F NONRATT023402.2 levels in the right striatum of LID rats treated with L-DOPA for 2, 4, 6, 8, and 10 weeks and PD rats (n = 4–5). G Fluorescence in situ hybridization labeling of NONRATT023402.2 in the striatum of rats. Arrows and asterisks indicate neurons and astrocytes, respectively. Data represent the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001.

Back to article page