Fig. 3: The mRNA expression signatures of Sham + LID and LncRNA + LID group rats. | Cell Death Discovery

Fig. 3: The mRNA expression signatures of Sham + LID and LncRNA + LID group rats.

From: The NONRATT023402.2/rno-miR-3065-5p/NGFR axis affects levodopa-induced dyskinesia in a rat model of Parkinson’s disease

Fig. 3: The mRNA expression signatures of Sham + LID and LncRNA + LID group rats.

A Heat map of mRNA in the right striatum of LID rats with or without lncRNA-AAV injection (n = 3). B Schematic representation of the screening target genes process. The intersection of 118 up-regulated genes obtained by sequencing, and 9403 target genes predicted by the database were used, and then the NGFR was determined as the next research object according to the KEGG annotation and PPI network analysis. C PPI network of differentially-expressed genes. The nodes represent proteins, and the edges represent the interaction of proteins. D Four subgroups of the PPI network. E NGFR, NMU, GYS2, and ELK4 expressions determined by qRT-PCR in the right striatum of the Sham + LID group, and LncRNA + LID group rats (n = 3–4). F The rno-miR-3065-5p expression in the right striatum of the Sham + LID group and LncRNA + LID group rats (n = 3–4). Data represent the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001.

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