Fig. 1: Induction of ferroptosis and radiotherapy-induced ferroptosis.
From: Regulation of m6A modification on ferroptosis and its potential significance in radiosensitization
Excessive production of lipid peroxides can lead to ferroptosis. GPX4 helps to eliminate lipid peroxides and exerts anti-ferroptotic effects, which requires GSH to provide reducing power. SLC7A11 imports cystine into the cell, providing the substrate for the synthesis of GSH. Ionizing radiation induces the expression of ACSL4, which provides the substrate PUFA-PLs for lipid peroxidation. Ionizing radiation-mediated ROS consumes cellular GSH and promotes lipid oxidation.
