Fig. 1: Histopathological and molecular characterization of the tumor.
From: A primary luminal/HER2 negative breast cancer patient with mismatch repair deficiency
A Haematoxylin and eosin slide shows a ductal infiltrating breast carcinoma (G3) (scale bar represents 200 µm). B High magnification of panel A shows high cellular pleomorphism, absence of tubules and numerous mitoses (scale bar represents 20 µm). C Estrogen receptor expression in more than 95% of breast cancer cells (scale bar represents 200 µm). D Progesterone receptor expression in about 1% of breast cancer cells (scale bar represents 200 µm). E Image displays high proliferation index (Ki67 > 35%) (scale bar represents 200 µm). F In situ hybridization analysis of HER2 status demonstrates the amplification of HER2 gene (ErbB2/CEN17 ratio >2) (scale bar represents 10 µm). G Expression mRNA levels (TPM) of estrogen receptor 1 (ESR1), progesterone receptor (PR1), ERBB2 receptor tyrosine kinase 2 (HER2) and proliferation marker KI-67 (MKI67) for the patient (red triangle) and the clinical cohort (blue boxplot).
