Fig. 8: PL and 17-AAG synergize to inhibit the growth of colon cancer cells in vivo. | Cell Death Discovery

Fig. 8: PL and 17-AAG synergize to inhibit the growth of colon cancer cells in vivo.

From: Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells

Fig. 8: PL and 17-AAG synergize to inhibit the growth of colon cancer cells in vivo.The alternative text for this image may have been generated using AI.

A–C Combination treatment of 17-AAG (10 mg/kg) and PL (5 mg/kg) greatly inhibited tumor volume and weight (*p < 0.05, **p < 0.01). D HE staining of major organs. Scale bar = 75 µm. E The relative expression of MDA in tumor tissues. F–J The expression levels of p-JNK, ATF4, and CHOP were detected by western blot.

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